The median age for total hip arthroplasty (THA) is over 70 years with the corollary that many individuals have multiple multimorbidities. Despite the predicted improvement in quality of life, THA ...

6 South London and Maudsley NHS Foundation Trust, London, UK Introduction Self-harm and suicide are major public health concerns among children and adolescents. Many risk and protective factors for ...

Introduction Stroke events deeply affect not only the stroke survivor but also often the quality of life and physical and psychological health of the family and friends who care for them. There is a ...

Objective A growing body of evidence points to a role for herpesviruses in the development of Alzheimer’s disease (AD) and a ...

Introduction Neck pain (NP) is a common musculoskeletal complaint and is increasing in prevalence. Current clinical practice guidelines and systematic reviews recommended conservative, pharmacological ...

Objective To estimate the health and financial burden of adverse childhood experiences (ACEs) in England and Wales. Design The study combined data from five randomly stratified cross-sectional ACE ...

Rationale and objective Salt reduction remains a global challenge and different salt reduction strategies have been studied in China. This study is to systematically evaluate evidence from randomised ...

1 NIHR CLAHRC for North West London, Chelsea and Westminster Hospital, London, UK 2 Department of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK Setting A wide range ...

Objectives In Japan, frailty is a major risk factor for requiring long-term care, especially among older adults aged 75 years or older (ie, late-stage older adults). Both physical and social factors ...

Objectives Medical artificial intelligence (AI) has been used widely applied in clinical field due to its convenience and innovation. However, several policy and regulatory issues such as credibility, ...

11 South Western Ambulance Service NHS Foundation Trust, Plymouth, UK Introduction Within the UK, chest pain is one of the most common reasons for emergency (999) ambulance calls and the most common ...

Objectives To identify recent trends in chronic kidney disease (CKD) prevalence in England and explore their association with changes in sociodemographic, behavioural and clinical factors. Design ...